The Super Berberine™

What is

GlucoVantage® is the first commercially available brand of Dihydroberberine (DHB), which is an active metabolite of berberine.

Berberine has been shown to optimize blood sugar, improving insulin sensitivity and body composition. Dihydroberberine solves berberine’s limitations of low bioavailability and GI distress.

The Benefits:

Versus berberine, DHB has shown to be up to 5x more bioavailable/absorbable, and 2x longer-lasting (8 hours vs. 4 hours)

Improves insulin sensitivity and carbohydrate tolerance, supporting healthy blood glucose levels

Supports body composition via AMPK, preferentially driving carbohydrates to muscle rather than fat

Anti-aging support by reducing glycation end-products correlated with biological aging

Ketogenic-friendly by increasing plasma BHB (ketones). Reduced GI distress compared to berberine due to DHB being the gut’s active metabolite.

How It Works

GlucoVantage® enhances insulin sensitivity effectively as well as inhibits adipocyte (fat cell) growth. Supports a healthy blood glucose level and insulin level.

May have synergy with exogenous ketone or MCT administration (e.g. KetoVantage® or C8Vantage™).



Highly bioavailable form of berberine (up to 5x more effective)

More cost-effective alternative to berberine

Less potential GI distress than berberine

No Adulteration or Herbal Spiking (HPLC/HPTLC)

Non-GMO and derived from natural berberine

More Insulin Sensitivity, Glucose Disposal 

Dihydroberberine (DHB) is a metabolite of berberine. Interestingly, gut microbes reduce berberine into its tissue-read form of DHB, which is then converted back to berberine after absorption in intestinal tissues.

In other words, supplementation with DHB bypasses the rate-limiting step of microbial reduction. This is why DHB has significantly greater functional benefits compared to berberine. Supplementation with DHB mitigates potential GI distress that some experience with berberine, which is likely the result of poor absorption and/or microbial reduction.

How to Use

1 – 2

Servings per day

Timing: prior to meals

Topical application may have added benefits. 

May have synergy when co-administered with probiotics, exogenous ketones, and/or MCTs (e.g. KetoVantage® & C8VantageTM). 

100 – 200 mg

Per serving

Ways to use GlucoVantage:





Come Straight to the Source.

Please contact us for more scientific and technical information


Other Products

BHB Salts

MCT C8 Powder

L-β-Aminoisobutyric Acid